Aspirin ‘resistance’: role of pre-existent platelet reactivity and correlation between tests

Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance': a rebuttal.

BACKGROUND Clopidogrel is a widely used antithrombotic agent that inhibits the platelet P2Y(12) adenosine diphosphate (ADP) receptor. There is increasing interest in 'clopidogrel resistance'. OBJECTIVES To determine whether 'clopidogrel resistance' is accounted for by a pre-existent variability in platelet response to ADP. METHODS Platelet response to 20 microm ADP was analyzed by four inde...

Adrenoreceptors, platelet reactivity and clopidogrel resistance.

Thromb Haemost 2008; 100: 729–730 Platelet activation plays a central role in haemostasis and thrombosis. Antiplatelet therapy is considered to be the ‘cornerstone’in the prevention and treatment of thrombotic diseases such as coronary artery disease (CAD), stroke and peripheral arterial disease (PAD). While dual antiplatelet therapy with aspirin and clopidogrel is currently the standard therap...

Aspirin treatment reduces platelet resistance to deformation.

The present investigation has evaluated the influence of aspirin, its constituents, and other nonsteroidal anti-inflammatory agents on the resistance of human platelets to aspiration into micropipettes. Aspirin increased the length of platelet extensions into the micropipette over the entire negative tension range of 0.04 to 0.40 dynes/cm after exposure to the drug in vitro or after ingestion o...

Aspirin and platelet function

1 Freyssinet JM. Cellular microparticles: what are they bad or good for? J Thromb Haemost 2003; 1: 1655–62. 2 JyW,MaoWW,Horstman LL, Tao J, AhnYS. Platelet microparticles bind, activate and aggregate neutrophils in vitro. Blood Cells Molecules Dis 1995; 21: 217–31. 3 Jy W, Horstman LL, Arce M, Ahn YS. Clinical significance of platelet microparticles in autoimmune thrombocytopenias. J Lab Clin M...

Correlation between Different Patterns of Hypo-Osmotic Swelling and Sperm Functional Tests